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In the earlier Phase 2 trial, the highest dose tested (45 mg) produced 14.7% weight loss at 36 weeks, suggesting that longer treatment and dose optimization may yield further improvements

We now propose a feasible mechanism: Denley and colleagues [119] have beautifully designed a study where they demonstrate how IR has a splice variant lacking exon 11 which confers the receptor affinity for IGF-1 and IGF-2

PubMed Phase-III trials on Tesamorelin showed 8 % visceral-fat reduction in 69 % of users versus 33 % on placebo

Self-experimentation with drug dosages, such as microdosing, should be avoided

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